Role of cannabinoids in alcohol-induced neuroinflammation

Alcohol is a psychoactive substance highly used worldwide, whose harmful use might cause broad range of mental and behavioural disorders. Underlying brain impact, the neuroinflammatory response induced by alcohol recognised as key contributing factor in progression other neuropathological processes, such neurodegeneration. These sequels are determined multiple factors, including age exposure. Strikingly, it seems that endocannabinoid system modulation could regulate alcohol-induced neuroinflammation. Although direct CB1 activation can worsen consequences, targeting components expanded may counterbalance pro-inflammatory response. Indeed, specific modulations have been proved to exert anti-inflammatory effects, primarily through CB2 PPAR? signalling. Among them, some endo- exogeneous cannabinoids block certain mediators, NF-?B, thereby neutralizing intracellular cascades. Furthermore, number able activate complementary pathways, which necessary for transition from chronically overactivated microglia regenerative microglial phenotype. Thus, cannabinoid provides cooperative mechanisms be advantageous resolve pathological neuroinflammation an alcohol-dependent context.